The Dangers of Poppers

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The Bottom Line

Poppers are recreational drugs containing alkyl nitrites. They are used for muscle relaxation and aphrodisia but using them can cause low oxygen levels, difficulty breathing, and feeling faint. In severe or untreated cases, death can occur. Due to the severe health problems that can occur with the use of poppers, the FDA has warned consumers not to use these products.

The Full Story

In June 2020, the FDA issued a warning about the dangers of poppers. Popular in the LGBTQ community, poppers have been used since the 1970’s as a recreational drug, for the purposes of muscle relaxation and sexual enhancement. Poppers contain organic nitrite compounds such as amyl nitrite, isopropyl nitrite, and isobutyl nitrite. These compounds were initially used for the treatment of heart disease and were often packaged in glass vials. The vials had to be broken, or popped, to access the drug inside, leading to the now-familiar name “poppers.”

Today, poppers can be purchased online, at gas stations, or at adult novelty stores. They are often sold in 10-15 mL bottles with brand names including “Rush,” “Jungle Juice,” or “Liquid Gold,” and are often marketed as room “deodorizers,” leather cleaners, head cleaners, or nail polish removers. The packaging and bottle size may appear similar to energy shot drinks, and this may lead to confusion and unintentional poisoning. Poppers are also used intentionally, but unfortunately, many individuals are unaware of their potential harmful effects.

When ingested or inhaled, even in small amounts, poppers can cause a life-threatening condition called methemoglobinemia. Methemoglobinemia results in decreased delivery of oxygen to the body’s tissues and organs. Patients affected by methemoglobinemia often have low oxygen levels and may feel lightheaded or have chest pain, difficulty breathing, or headaches.  In severe cases, death can occur. There is an antidote for methemoglobinemia, but it is only available in hospital settings.

The use of poppers is also known to cause eye problems, including visual changes, light sensitivity, and blind spots. In addition, poppers may contain ingredients other than nitrites which may be damaging to the skin. There have been cases of rashes and wounds that occurred after leakage of popper fluid onto skin.

If you suspect a poisoning while using poppers, use the webPOISONCONTROL® online tool or call 1-800-222-1222. Both options are free for the public, and available 24 hours a day.

Kelly Johnson-Arbor, MD
Medical Toxicology PhysicianShare this:    


For More Information

US Food and Drug Administration. FDA advises consumers not to purchase or use nitrite “poppers.” Accessed July 10, 2021.


References

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Moret F, Lindner G, Woitok BK. The Untimely Popping Phial: Poppers as an Unusual Cause of Skin Corrosion of the Thigh. Case Rep Emerg Med. 2020 Jan 30;2020:2058624.

Nossaman VE, Nossaman BD, Kadowitz PJ. Nitrates and nitrites in the treatment of ischemic cardiac disease. Cardiol Rev. 2010 Jul-Aug;18(4):190-7.

Schwartz C, Fast D, Knight R. Poppers, queer sex and a Canadian crackdown: Examining the experiences of alkyl nitrite use among young sexual minority men. Int J Drug Policy. 2020 Mar;77:102670. doi: 10.1016/j.drugpo.2020.102670.

Sega R, Urbancic M. Waxing and waning poppers maculopathy. Can J Ophthalmol. 2021 Jun;56(3):e101-e103.

Tello DM, Doodnauth AV, Patel KH, Gutierrez D, Dubey GR. Poppers-Induced Methemoglobinemia: A Curious Case of the Blues. Cureus. 2021 May 27;13(5):e15276. 

US Food and Drug Administration. FDA advises consumers not to purchase or use nitrite “poppers”. Accessed July 10, 2021.

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